A recent study conducted by Giulia Frazzei from the Department of Rheumatology and Clinical Immunology at Amsterdam University Medical Centers has uncovered four clinical variables that significantly predict the development of rheumatoid arthritis (RA) in patients with seropositive arthralgia. Published online on February 15, 2025, in the Annals of the Rheumatic Diseases, the study was supported by the Dutch Arthritis Association and the European Union's Horizon 2020 research and innovation programme.
The research identified being a first-degree relative of RA patients, experiencing intermittent symptoms, morning stiffness lasting at least one hour, and swollen joints as the four robust predictors associated with RA development. The study highlights that these variables can be easily assessed in clinical settings.
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