A groundbreaking test, known as the CARES test, has emerged as a significant advancement in predicting the risk of developing substance use disorders. Based on an extensive database derived from over 1.5 million individuals, this innovative assessment offers a comprehensive understanding of genetic, environmental, and behavioral factors contributing to addiction risk. Developed by researchers at the Rutgers Addiction Research Center in Piscataway, New Jersey, the test is poised to reshape how individuals approach their potential for addiction.
The CARES test harnesses insights from a 2021 study published in Nature Neuroscience, which identified a range of behavioral and medical outcomes linked to more than 500 locations within the human genome. This research established that DNA accounts for approximately half of the reasons some individuals develop addiction, while environmental and behavioral influences play a substantial role as well.
Danielle Dick, PhD, a prominent researcher in the field, emphasized the importance of this comprehensive approach. “If anyone tells you that they're genotyping just a few genes, then that is not state-of-the-science anymore,” she stated. “That is not what scientists are doing at all in the field. That's what we were doing a decade ago.” The CARES test sets itself apart by analyzing a wide array of genetic factors, providing a more accurate risk assessment.
The test specifically targets "externalizing" behaviors and disorders, such as issues with behavioral regulation and impulsivity. By understanding these tendencies, individuals can gain valuable insights into their potential risk for substance use disorders. The CARES test not only provides a risk estimate ranging from low to high but also highlights environmental or behavioral factors that individuals may consider addressing to mitigate their risk.
Participants can access the test for a fee of $149, which covers processing and administrative costs. After submitting a DNA sample via mail, individuals can expect results within approximately six weeks. The report will include a risk estimate alongside actionable information about what that risk entails. As Dick noted, “Once you understand something about your risk, we also want to help you understand what that means.”
In addition to assessing genetic predisposition, the CARES test aims to alleviate feelings of guilt often experienced by those struggling with addiction. It promotes the idea that genes do not dictate destiny. “Knowledge is power, and we're trying to give that power,” Dick explained, encouraging individuals to take proactive steps toward better health based on their unique circumstances.
The CARES test offers more than just results; it provides a pathway for further engagement with researchers. Individuals can connect with experts for personalized guidance on interpreting their results and understanding the implications for their lives. This connection ensures that participants are not navigating their journey alone but rather have access to resources that can help them make informed decisions.
The CARES test underscores the growing acknowledgment that addiction is a complex interplay of genetics and environment rather than a simple matter of personal choice. J9 Austin, PhD, highlighted an essential aspect of how this information is perceived: “It's how it's received that matters.” By fostering an environment where individuals feel empowered rather than judged, the test promotes a healthier dialogue around addiction.
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